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Aconitum alkaloid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) GABA Receptor (1) NF-κB (1) P2X Receptor (1) Parasite (1) Potassium Channel (3) Sodium Channel (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (4) Endocrinology (1) Infection (1) Inflammation/Immunology (2) Neurological Disease (4)

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Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N9404

6-Benzoylheteratisine	Sodium Channel	Neurological Disease
6-Benzoylheteratisine is an Aconitum alkaloid with potential neuroprotective activity. 6-Benzoylheteratisine can antagonize tetrodotoxin, inhibit the increase of [Na ⁺]i, [Ca ²⁺]i and glutamate release, and block sodium channels. 6-Benzoylheteratisine has an inhibitory effect on the neuronal activity underlying epileptiform burst discharge .

HY-N3177

Norglaucine hydrochloride

Others Others

Norglaucine hydrochloride is an alkaloid that can be isolated from Aconitum carmichaelii .
HY-N3203

Neolinine

Others Others

Neolinine is a diterpenoid alkaloid that can be isolated from the aerial parts of Aconitum carmichaeli .
HY-N11436

Aconicarchamine B

Others Others

Aconicarchamine B is a C20-diterpenoid alkaloid, which can be isolated from Aconitum carmichaelii .

Norglaucine hydrochloride	Others	Others
Norglaucine hydrochloride is an alkaloid that can be isolated from Aconitum carmichaelii .

Neolinine	Others	Others
Neolinine is a diterpenoid alkaloid that can be isolated from the aerial parts of Aconitum carmichaeli .

Aconicarchamine B	Others	Others
Aconicarchamine B is a C20-diterpenoid alkaloid, which can be isolated from Aconitum carmichaelii .

HY-125559

Jesaconitine	Others	Cardiovascular Disease
Jesaconitine is a toxic alkaloid. Jesaconitine can be derived from Aconitum. Jesaconitine is one of the major metabolites that can be detected in the blood of the right atrium after aconitum poisoning. Various types of arrhythimia are characteristic in aconitine intoxication .

HY-N0333

Yunaconitine

Guayewuanine B
Others Cardiovascular Disease

Yunaconitine(Guayewuanine B) is a highly toxic aconitum alkaloid.
HY-N4163

Acoforestinine

Others Others

Acoforestinine is a diterpenoid alkaloid isolated from Aconitum handelianum .
HY-N1946

Chasmanine

Others Others

Chasmanine is an alkaloid isolated from the roots of Aconitum crassicaule .
HY-N1974

Fuziline

15α-Hydroxyneoline

Fuziline is a alkaloid isolated from the lateral roots of Aconitum carmichaelii .

Yunaconitine Guayewuanine B	Others	Cardiovascular Disease
Yunaconitine(Guayewuanine B) is a highly toxic aconitum alkaloid.

Acoforestinine	Others	Others
Acoforestinine is a diterpenoid alkaloid isolated from Aconitum handelianum .

Chasmanine	Others	Others
Chasmanine is an alkaloid isolated from the roots of Aconitum crassicaule .

Fuziline 15α-Hydroxyneoline
Fuziline is a alkaloid isolated from the lateral roots of Aconitum carmichaelii .

HY-N0850

Benzoylhypaconine Benzoylhypacoitine	Others	Neurological Disease
Benzoylhypaconine (Benzoylhypacoitine) is a monoester Aconitum alkaloid, is the main pharmacologic and toxic component .

HY-N0851

Foresaconitine

Vilmorrianine C
Others Others

Foresaconitine(Vilmorrianine C) is a norditerpenoid alkaloid isolated from the processed tubers of Aconitum carmichaeli.
HY-N1010

10-Hydroxyneoline

Others Others

10-Hydroxyneoline is a diterpene alkaloid compound isolated from Aconitum fukutomei .
HY-N11453

Carmichasine B

Others Others

Carmichasine B is a natural diterpenoid Alkaloid that can be isolated from Aconitum carmichaelii .
HY-N10099

Forestine

Others Others

Forestine is a natural C₁₉-diterpenoid alkaloid found in the roots of Aconitum forrestii Stapf .

Foresaconitine Vilmorrianine C	Others	Others
Foresaconitine(Vilmorrianine C) is a norditerpenoid alkaloid isolated from the processed tubers of Aconitum carmichaeli.

10-Hydroxyneoline	Others	Others
10-Hydroxyneoline is a diterpene alkaloid compound isolated from Aconitum fukutomei .

Carmichasine B	Others	Others
Carmichasine B is a natural diterpenoid Alkaloid that can be isolated from Aconitum carmichaelii .

Forestine	Others	Others
Forestine is a natural C₁₉-diterpenoid alkaloid found in the roots of Aconitum forrestii Stapf .

HY-N7002

Nagarine 10-Hydroxy aconitine	Others	Neurological Disease Inflammation/Immunology
Nagarine, an alkaloid isolated from the roots of Aconitum* nagarum Stapf* (Ranunculaceae), is used to treat Rheumatic and neuralgic disorders .

HY-N1923

Hypaconine

Hypaconine is a C19-diterpenoid alkaloid isolated from Aconitum and Delphinium spp. Hypaconine exhibits strong cardiac activity .

Hypaconine
Hypaconine is a C19-diterpenoid alkaloid isolated from Aconitum and Delphinium spp. Hypaconine exhibits strong cardiac activity .

HY-N0663

Talatisamine	Potassium Channel	Neurological Disease
Talatisamine, a aconitum alkaloid, is specific K ⁺ channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons .

HY-N6812

Karacoline	NF-κB	Endocrinology
Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway .

HY-N5006

Guanfu base G	Potassium Channel	Cardiovascular Disease
Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits HERG channel current with an IC₅₀ of 17.9 μM .

HY-N2162

12-Epinapelline
12-Epinapelline is a diterpene alkaloid isolated from Aconitum baikalense. 12-Epinapelline exhibits Anti-inflammatory activity and stimulates the growth of colonies from fibroblast precursors .

HY-N1924

Crassicauline A Crassicaulin A
Crassicauline A (Crassicaulin A) is a bioactive alkaloid found in roots of Aconitum carmichaeli. Crassicauline A (Crassicaulin A) possesses feeding deterrent activity against T. castaneum adults with an EC₅₀ of 1134.5 ppm .

HY-N2080

Songorine	GABA Receptor	Cancer
Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC) .

HY-N5005

Guanfu base H Atisinium chloride	Parasite	Infection
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial *Plasmodium falciparum* strains TM4/8.2 (wild type) and K1CB1 with IC₅₀ values of 4 μM and 3.6 μM, respectively .

HY-N5025

Bullatine A	P2X Receptor Apoptosis	Inflammation/Immunology Cancer
Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses . Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed .

HY-N1483

Guanfu base A	Potassium Channel	Cardiovascular Disease
Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a K_i of 1.20 μM in human liver microsomes (HLMs) and a K_i of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (K_i of 0.38 μM) and dog (K_i of 2.4 μM) microsomes . Guanfu base A also inhibits HERG channel current .

6-Benzoylheteratisine	Alkaloids Piperidine Alkaloids Structural Classification Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants	Sodium Channel
6-Benzoylheteratisine is an Aconitum alkaloid with potential neuroprotective activity. 6-Benzoylheteratisine can antagonize tetrodotoxin, inhibit the increase of [Na ⁺]i, [Ca ²⁺]i and glutamate release, and block sodium channels. 6-Benzoylheteratisine has an inhibitory effect on the neuronal activity underlying epileptiform burst discharge .

Norglaucine hydrochloride	Structural Classification Alkaloids Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants Isoquinoline Alkaloids	Others
Norglaucine hydrochloride is an alkaloid that can be isolated from Aconitum carmichaelii .

Neolinine	Structural Classification Alkaloids Other Alkaloids Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants	Others
Neolinine is a diterpenoid alkaloid that can be isolated from the aerial parts of Aconitum carmichaeli .

Aconicarchamine B	Structural Classification Terpenoids Source classification Ranunculaceae Diterpenoids Aconitum carmichaeli Debx. Plants	Others
Aconicarchamine B is a C20-diterpenoid alkaloid, which can be isolated from Aconitum carmichaelii .

Jesaconitine	Structural Classification Alkaloids Other Alkaloids Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants	Others
Jesaconitine is a toxic alkaloid. Jesaconitine can be derived from Aconitum. Jesaconitine is one of the major metabolites that can be detected in the blood of the right atrium after aconitum poisoning. Various types of arrhythimia are characteristic in aconitine intoxication .

Yunaconitine Guayewuanine B	Cardiovascular Disease Alkaloids Classification of Application Fields Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants Disease Research Fields	Others
Yunaconitine(Guayewuanine B) is a highly toxic aconitum alkaloid.

Acoforestinine	Classification of Application Fields Terpenoids Source classification Ranunculaceae Other Diseases Diterpenoids Aconitum carmichaeli Debx. Plants Disease Research Fields	Others
Acoforestinine is a diterpenoid alkaloid isolated from Aconitum handelianum .

Chasmanine	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Ranunculaceae Source classification Other Diseases Aconitum carmichaeli Debx. Plants Disease Research Fields	Others
Chasmanine is an alkaloid isolated from the roots of Aconitum crassicaule .

Benzoylhypaconine Benzoylhypacoitine	Alkaloids Pyrrole Alkaloids Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants	Others
Benzoylhypaconine (Benzoylhypacoitine) is a monoester Aconitum alkaloid, is the main pharmacologic and toxic component .

Foresaconitine Vilmorrianine C	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Ranunculaceae Other Diseases Aconitum carmichaeli Debx. Plants Disease Research Fields	Others
Foresaconitine(Vilmorrianine C) is a norditerpenoid alkaloid isolated from the processed tubers of Aconitum carmichaeli.

Carmichasine B	Structural Classification Terpenoids Source classification Ranunculaceae Diterpenoids Aconitum carmichaeli Debx. Plants	Others
Carmichasine B is a natural diterpenoid Alkaloid that can be isolated from Aconitum carmichaelii .

Forestine	Structural Classification Alkaloids Other Alkaloids Ranunculaceae Source classification Aconitum forrestii Stapf Plants	Others
Forestine is a natural C₁₉-diterpenoid alkaloid found in the roots of Aconitum forrestii Stapf .

Nagarine 10-Hydroxy aconitine	Aconitum nagarum var. lasiandrum W. T. Wang Structural Classification Alkaloids Other Alkaloids Ranunculaceae Source classification Plants	Others
Nagarine, an alkaloid isolated from the roots of Aconitum* nagarum Stapf* (Ranunculaceae), is used to treat Rheumatic and neuralgic disorders .

Talatisamine	Alkaloids Pyrrole Alkaloids Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants	Potassium Channel
Talatisamine, a aconitum alkaloid, is specific K ⁺ channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons .

Karacoline	Structural Classification Classification of Application Fields Terpenoids Source classification Ranunculaceae Diterpenoids Aconitum carmichaeli Debx. Plants Disease Research Fields Endocrinology	NF-κB
Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway .

Guanfu base G	Cardiovascular Disease Alkaloids Classification of Application Fields Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants Disease Research Fields Indole Alkaloids	Potassium Channel
Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits HERG channel current with an IC₅₀ of 17.9 μM .

Songorine	Alkaloids Aconitum soongaricum Stapf Classification of Application Fields Source classification Ranunculaceae Plants Disease Research Fields Cancer	GABA Receptor
Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC) .

Guanfu base H Atisinium chloride	Infection Alkaloids Classification of Application Fields Source classification Ranunculaceae Quinoline Alkaloids Aconitum carmichaeli Debx. Plants Disease Research Fields	Parasite
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid isolated from Aconitum coreanum and has antiplasmodial activity against the malarial *Plasmodium falciparum* strains TM4/8.2 (wild type) and K1CB1 with IC₅₀ values of 4 μM and 3.6 μM, respectively .

Bullatine A	Structural Classification Alkaloids Piperidine Alkaloids Classification of Application Fields Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants Inflammation/Immunology Disease Research Fields	P2X Receptor Apoptosis
Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses . Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed .

Guanfu base A	Cardiovascular Disease Alkaloids Classification of Application Fields Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants Disease Research Fields	Potassium Channel
Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a K_i of 1.20 μM in human liver microsomes (HLMs) and a K_i of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (K_i of 0.38 μM) and dog (K_i of 2.4 μM) microsomes . Guanfu base A also inhibits HERG channel current .

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Aconitum alkaloid

Inhibitors & Agonists

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Natural
Products